Wins
| Academy Awards: Rain Man (1989) | Best Actor in Leading Role |
| Academy Awards: Kramer vs. Kramer (1980) | Best Actor in Leading Role |
| Annie Awards: Kung Fu Panda (2008) | Best Voice Acting in Animated Feature |
| BAFTA Award: Tootsie (1982) | Best Actor |
| BAFTA Award: John and Mary (1969) | Best Actor |
| BAFTA Award: The Graduate (1967) | Most Promising Newcomer to Leading Film |
| Boston Society of Film Critics Awards: Tootsie (1982) | Best Actor |
| David di Donatello Awards: Rain Man (1988) | Best Foreign Actor |
| David di Donatello Awards: Kramer vs. Kramer (1979) | Best Foreign Actor |
| David di Donatello Awards: Marathon Man (1976) | Best Foreign Actor |
| David di Donatello Awards: Midnight Cowboy (1969) | Best Foreign Actor |
| Emmy Award: Death of a Salesman (1985) | Outstaning Lead Actor in a Mini-series or Special
|
| The Golden Globes: (1997) | Cecil B. DeMille Award |
| The Golden Globes: Rain Man (1988) | Best Actor in motion picture: Drama |
| The Golden Globes: Death of a Salesman (1985) | Best Actor in mini-series or TV |
| The Golden Globes: Tootsie (1982) | Best Actor in motion picture: Comedy |
| The Golden Globes: Kramer vs. Kramer (1979) | Best actor in motion picture: Drama |
| The Golden Globes: The Graduate (1967) | Most Promising Newcomer (Male) |
| Kansas City Film Critics Circle Awards: Rain Man (1988) | Best Actor |
| Kansas City Film Critics Circle Awards: Kramer vs. Kramer (1979) | Best Actor |
| Laurel Awards: (1971) | Best Male Star |
| Laurel Awards: Midnight Cowboy (1969) | Best (Male) Dramatic Performance |
| Los Angeles Film Critics Association Awards: Kramer vs. Kramer (1979) | Best Actor |
| MTV Movies Awards: Meet The Fockers (2004) | Best Comedic Performance |
| National Society of Film Critics Awards, USA: Tootsie (1982) | Best Actor |
| National Society of Film Critics Awards, USA: Kramer vs. Kramer (1979) | Best Actor |
| New York Film Critics Circle Awards: Kramer vs. Kramer (1979) | Best Actor |
| People's Choice Awards, USA: (1990) | World-Favorite Motion Picture Actor |
| People's Choice Awards, USA: (1989) | Favorite Dramatic Motion Picture Actor |
Nominations
| The Academy Awards: Wag The Dog (1997) | Best Actor in Leading Role |
| The Academy Awards: Tootsie (1982) | Best Actor in Leading Role |
| The Academy Awards: Lenny (1974) | Best Actor in Leading Role |
| The Academy Awards: Midnight Cowboy (1969) | Best Actor in Leading Role |
| The Academy Awards: The Gradaute (1967) | Best Actor in Leading Role |
| BAFTA Awards: Rain Man (1988) | Best Actor |
| BAFTA Awards: Kramer vs. Kramer (1979) | Best Actor |
| BAFTA Awards: All The President's Men (1976) | Best Actor |
| BAFTA Awards: Lenny (1974) | Best Actor |
| BAFTA Awards: Little Big Man (1970) | Best Actor |
| Daytime Emmy Awards: The Devil's Arithmetic (1999) | Outstanding Children's Special |
| Emmy Awards: Death of a Salesman (1985) | Outstanding Drama/Comedy Special |
| The Golden Globes: Last Chance Harvey (2008) | Best Motion Picture Actor - Comedy or Musical |
| The Golden Globes: Wag the Dog (1997) | Best Motion Picture Actor - Comedy/Musical |
| The Golden Globes: Hook (1991) | Best Motion Picture Actor - Comedy/Musical |
| The Golden Globes: Marathon Man (1976) | Best Motion Picture Actor - Drama |
| The Golden Globes: Lenny (1974) | Best Motion Picture Actor - Drama |
| The Golden Globes: Midnight Cowboy (1969) | Best Motion Picture Actor - Drama |
| The Golden Globes: John and Mary (1969) | Best Motion Picture Actor - Musical/Comedy |
| The Golden Globes: The Graduate (1967) | Best Motion Picture Actor - Musical/Comedy |
| Laurel Awards: The Graduate (1967) | Male Comedy Performance |
| Satellite Awards: Wag the Dog (1997) | Best Performance by an Actor in a Motion Picture - Comedy or Musical |
| Screen Actors Guild Awards: Finding Neverland (2004) | Outstanding Performance by a Cast in a Motion Picture |
| Screen Actors Guild Awards: Wag the Dog (1997) | Outstanding Performance by a Male Actor in a Leading Role |
Theater
| Theater World Awards (1967) | Best Actor: Eh? |
| Vernon Rice Award (1966) | Best Actor: Eh? |
| Drama Desk Award (1966) | Best Actor: Eh? |
| Drama Desk Award (1968) | Best Actor: Jimmy Shine |
| Drama Desk Award (1984) | Best Actor: Death of a Salesman |
| Village Voice off Broadway Awards (1965-1966) | Best Actor: Journey of the Fifth Horse |
Other Awards
| American Film Institute, USA (1999) | Life Achievement Award |
| BAFTA/LA Britannia Awards (1997) | Britannia Award |
| Berlin International Film Festival (1989) | Honorary Golden Berlin Bear |
| Chicago International Film Festival (2006) | Career Achievement Award |
| CineVegas International Film Festival (2002) | Marquee Award |
| Costume Designers Guild Awards (2003) | Distinguished Actor Award |
| César Awards, France (2009) | Honorary César |
| Empire Awards, UK (2003) | Lifetime Achievement Award |
| Film Society of Lincoln Center (2005) | Gala Tribute |
| Golden Camera, Germany (2003) | Golden Camera for Lifetime Achievement |
| Hasty Pudding Theatricals, USA (1972) | Man Of The Year |
| Hollywood Film Festival (2008) | Lifetime Achievement Award |
| Hollywood Makeup Artist and Hair Stylist Guild Awards (2002) | Barrymore Award |
| Palm Springs International Film Festival (2009) | Chairman's Award |
| San Francisco International Film Festival (2003) | Peter J. Owens Award |
| Venice Film Festival (1996) | Career Golden Lion |
| Laurel Awards (1971) | Best Comedy Performance, Male Male New Face3rd Place (Golden Laurel) |
| Laurel Awards (1970) | Male Star2nd Place (Golden Laurel) |
| Laurel Awards (1968) | 2nd Place (Golden Laurel) |